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Synthesis and mass spectral fragmentation patterns of some nitrogen heterocycles with antimicrobial activity.
- Source :
-
Research on Chemical Intermediates . Feb2014, Vol. 40 Issue 2, p887-901. 15p. - Publication Year :
- 2014
-
Abstract
- 5-( P-tolyl)-2-[(3-bromo-4-methoxy benzylidene) hydrazino]-thiazole 3, 3-[(3-bromo-4-mehtoxy benzylidine) amino]-2-thiohydantion 5, and 4,6-disubstituted-3-[(3-bromo-4-methoxybenzyliden) amino]-2-thioxo pyrimidines 10 have been prepared via cyclization of 3-bromo-4-methoxy benzaldehyde thiosemicarbazone 2 with 4-methyl phenacyl bromide, ethyl chloroacetate, and dicarbonyl compounds in different conditions. Acetylation of 3 and 5 with acetic anhydride gave the corresponding monoacetyl derivatives 4 and 6, while the acetylation of 5 with acetic anhydride in the presence of fused sodium acetate gave diacetyl derivative 7. Condensation of compound 5 with benzaldehyde in the presence of piperidine yielded the corresponding 3-substituted-5-benzylindene 2-thiohydation 8. Acetylation of compound 8 with acetic anhydride gave the corresponding 1-acetyl-3-substituted-5-benzylidene-2-thiohydantion 9. The mass spectral fragmentation patterns of some prepared compounds are investigated in order to elucidate the structure of the synthesized nitrogen heterocycles. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09226168
- Volume :
- 40
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Research on Chemical Intermediates
- Publication Type :
- Academic Journal
- Accession number :
- 93675749
- Full Text :
- https://doi.org/10.1007/s11164-012-1009-8