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PPAR-γ agonist stabilizes KLF4 protein via activating Akt signaling and reducing KLF4 ubiquitination.
- Source :
-
Biochemical & Biophysical Research Communications . Jan2014, Vol. 443 Issue 2, p382-388. 7p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] PPAR-γ increases KLF4 protein level but does not influence KLF4 gene transcription. [•] The increase of KLF4 protein levels induced by pioglitazone is PPAR-γ-dependent. [•] Pioglitazone stabilizes KLF4 protein via activating Akt signaling and reducing KLF4 ubiquitination. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 443
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 93655218
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.11.129