PORCINE CIRCOVIRUS-2 IMPACT ON THE MORPHOLOGICAL SIGHT OF PIG LYMPH NODES.

The aim of study was to investigate porcine circovirus-2 (PCV2) impact on the morphological sight of pig lymph nodes. The research was carried out in 2010. Three Latvian farms were investigated (from Latgale and Kurzeme) and thirty 5-15 weeks old pigs with clinical signs of Postweanig Multisystemic Wasting Syndrome were selected and observed. Four lymph nodes from each animal for histological and immunohistochemical investigations were taken. Thirty structural parameters of a lymph node were detected on histological slides: visualization of follicle structure, lymphocyte depletion and amount of histiocytic cell infiltration. As a result, changes in lymph nodes with PCV2 antigen were detected in all these structural parameters: increasing amount of PCV2 antigen in pig lymph nodes, but the greatest changes were in the follicles structure in lymph node. The increased amount of PCV2 antigen in lymph node, significantly decreases the amount of lymphocytes and increases the amount of histiocytes in them. Porcine circoviruss-2 in lymph node basically distributes from the lymph node cortex into the medulla, as well the amount of PCV2 antigen in lymph node also increased. [ABSTRACT FROM AUTHOR]