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Paediatric patients with inflammatory bowel disease who received infliximab experienced improved growth and bone health.
- Source :
-
Acta Paediatrica . Feb2014, Vol. 103 Issue 2, pe69-e75. 7p. - Publication Year :
- 2014
-
Abstract
- Aim Children with inflammatory bowel disease ( IBD) have a high prevalence of growth retardation and low bone mineral density ( BMD). This retrospective study investigated whether the start of infliximab treatment ( IFX) was associated with improvement of growth and bone health. Methods Anthropometry, BMD and bone markers were measured 1 year before and after the start of IFX treatment in 33 patients (51% males), with a median age of 13.5 years at baseline. Outcomes were growth with treatment and indicators of improved bone health. Results Twenty-one children (64%) experienced a positive catch-up growth after IFX. Height standard deviation scores ( SDS) were significantly higher in children in remission. Treatment with IFX was associated with a statistically significant increase in 25-hydroxycholecalciferol (25- OHD, p = 0.01). IFX had no influence on BMD. Children with low BMD < −2 had significantly higher inflammation scores, lower body mass index, weight, height SDS and 25- ODH after IFX. Conclusion After treatment with IFX, children with IBD improved significantly in weight, with the majority achieving positive catch-up growth. Bone mass tended to remain static with time of treatment with IFX, despite a significant increase in 25- OHD. Improved nutritional status positively predicts improved bone mineralisation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08035253
- Volume :
- 103
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Acta Paediatrica
- Publication Type :
- Academic Journal
- Accession number :
- 93630403
- Full Text :
- https://doi.org/10.1111/apa.12448