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Chemical constituents from Aphanamixis grandifolia.
- Source :
-
Fitoterapia . Jan2014, Vol. 92, p100-104. 5p. - Publication Year :
- 2014
-
Abstract
- Abstract: Four new terpenoids, nemoralisins D–G (1–4), were isolated from the leaves and stems of Aphanamixis grandifolia, along with two known diterpenoids, nemoralisin C and nemoralisin. Among them, compound 1 is the first example of norsesquiterpenoid with δ-lactone moiety, and nemoralisins E–G (2–4), are a class of acyclic diterpenoids, which are structurally related nemoralisin C and nemoralisin. These structures were established on the basis of spectroscopic methods and the absolute configuration of 1 was determined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Nemoralisins D–G (1–4) were tested for their cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines (IC50 >40 μM), as well as the antimicrobial activities on Staphylococcus aureus, Pseudomonas aeruginosa, MRSA92# and MRSA98# (MIC>50 μg/mL). [Copyright &y& Elsevier]
- Subjects :
- *ADENOCARCINOMA
*HEPATOCELLULAR carcinoma
*LEUKEMIA
*COLON tumor prevention
*ALTERNATIVE medicine
*ANTI-infective agents
*ANTINEOPLASTIC agents
*BIOLOGICAL models
*DOSE-effect relationship in pharmacology
*LEAVES
*MEDICINAL plants
*MICROBIAL sensitivity tests
*PSEUDOMONAS
*SPECTRUM analysis
*STAPHYLOCOCCUS aureus
*PLANT stems
*PLANT extracts
*METHICILLIN-resistant staphylococcus aureus
*DESCRIPTIVE statistics
*IN vitro studies
*PHARMACODYNAMICS
*PREVENTION
BREAST tumor prevention
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 92
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 93593180
- Full Text :
- https://doi.org/10.1016/j.fitote.2013.10.014