Determining the efficacy of temporary mandibular advancement splint in mild to moderate obstructive sleep apnea patients at baseline polysomnography.

Introduction: Mandibular advancement splint (MAS) have become increasingly popular as alternatives to continuous positive airway pressure (CPAP) for the treatment of obstructive sleep apnea (OSA). However,the acceptance of MAS is limited to the efficacy rate of 50–70% and inability to predict which patients will respond to this treatment. To overcome this limitation,the temporary mandibular advancement titration was performed in mild to moderate OSA patients dsuring baseline polysomnography (PSG) Objective: To determine the efficacy of temporary mandibular advancement splint in mild to moderate OSA patients during baseline polysomnography (PSG). Materials and methods: This pilot study consisted of ten undiagnosed subjects with OSA symptoms. The Temporary mandibular advancement splint,fabricated at 50% and 70% of maximum jaw protrusion, had been delivered to all subjects before each subject underwent baseline PSG. After the first half of the night,five subjects had severe OSA (AHI>30) and CPAP titration was performed in this group,four subjects had mild to moderate OSA (AHI 5–30) and temporary mandibular advancement splint titration was performed in this group, one subjects was normal (AHI<5) and no any device was performed on this subject. Results: Mean apnea–hypopnea index (AHI) was significantly reduced from 20.60(SD 8.28) to 5.65(SD 4.49) after treatment with Temporary mandibular advancement splint (p <0.05).Three patients were considered treatment success and one patient was considered treatment failure as defined by AHI<5. Conclusion: This pilot study shows that it is possible to utilize temporary mandibular advancement splint titration in mild to moderate OSA patients during baseline PSG and these results suggest that temporary mandibular advancement splint can be used as a tool in predicting treatment response in terms of efficacy piro to oral appliance therapy by means of using mandibular advancement splint in treating OSA. Acknowledgements: This study is granted by dental department,Phramongkutklao hospital, Bangkok, Thailand. [Copyright &y& Elsevier]