Back to Search
Start Over
Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial.
- Source :
-
Respiratory Research . Sep2012, Vol. 13 Issue 9, p1-9. 9p. 1 Diagram, 5 Charts, 3 Graphs. - Publication Year :
- 2012
-
Abstract
- Rationale: Pulmonary rehabilitation is an important treatment for patients with Chronic Obstructive Pulmonary Disease, who are often vitamin D deficient. As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease. Material and methods: This study is a post-hoc subgroup analysis of a larger randomized trial comparing a monthly dose of 100.000 IU of vitamin D with placebo to reduce exacerbations. 50 Subjects who followed a rehabilitation program during the trial are included in this analysis. We report changes from baseline in muscle strength and exercise performance between both study arms after 3 months of rehabilitation. Results: Vitamin D intervention resulted in significantly higher median vitamin D levels compared to placebo (51 [44-62] ng/ml vs 15 [13-30] ng/ml; p < 0.001). Patients receiving vitamin D had significantly larger improvements in inspiratory muscle strength (-11 ± 12 cmH2O vs 0 ± 14 cmH2O; p = 0.004) and maximal oxygen uptake (110 ± 211 ml/min vs -20 ± 187 ml/min; p = 0.029). Improvements in quadriceps strength (15 ± 16 Nm) or six minutes walking distance (40 ± 55 meter) were not significantly different from the effects in the placebo group (7 ± 19 Nm and 11 ± 74 meter; p > 0.050). Conclusion: High dose vitamin D supplementation during rehabilitation may have mild additional benefits to training. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14659921
- Volume :
- 13
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Respiratory Research
- Publication Type :
- Academic Journal
- Accession number :
- 93580395
- Full Text :
- https://doi.org/10.1186/1465-9921-13-84