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Effect of systemic antibiotics on clinical and patient-reported outcomes of implant therapy - a multicenter randomized controlled clinical trial.
- Source :
-
Clinical Oral Implants Research . Feb2014, Vol. 25 Issue 2, p185-193. 9p. 1 Diagram, 3 Charts, 6 Graphs. - Publication Year :
- 2014
-
Abstract
- Objectives To determine the effect of various systemic antibiotic prophylaxis regimes on patient-reported outcomes and postsurgical complications in patients undergoing conventional implant installation. Material and methods Three hundred and twenty-nine healthy adults in need of conventional implant installation were randomly assigned to one of four groups: (i) preoperatively 2 g of amoxycillin 1 h before surgery (positive control, PC), (ii) postoperatively 2 g of amoxycillin immediately following surgery (test 1, T1), (iii) preoperatively 2 g of amoxycillin 1 h before and 500 mg thrice daily on days 2 and 3 after surgery (test 2, T2), (iv) preoperatively 2 g of placebo 1 h before surgery (negative control, NC). Subjects were examined clinically by blinded examiners over 8 weeks after implant installation. In addition, Visual Analogue Scales ( VAS) for pain, swelling, bruising and bleeding were obtained over 14 days. ANOVA was performed for the VAS. Chi-square tests were applied for postsurgical complications. Results All VAS scores were low for all groups and decreased over time ( P < 0.001). There were no significant differences for the VAS scores between the various groups at any time point ( P > 0.05). There was only a significant difference in flap closure at week 4, where NC had 5% of the subjects not achieving complete wound closure compared to 0% for the three other groups ( P = 0.01), with no other significant differences for any postsurgical complications ( P > 0.05). Conclusion For standard single implant placement, prophylactic systemic antibiotics either before or after, or before and after the surgical procedure do not improve patient-reported outcomes or prevalence of postsurgical complications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09057161
- Volume :
- 25
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Clinical Oral Implants Research
- Publication Type :
- Academic Journal
- Accession number :
- 93569331
- Full Text :
- https://doi.org/10.1111/clr.12098