Regio- and Stereospecific Uncatalyzed Reactions ofElectron-Rich Arenes and Olefins at Organomolybdenum EnantiomericScaffolds.

A novel uncatalyzed reaction betweenTpMo(CO)2(5-trifluoroacetoxy-η3-5,6-dihydropyranyl/dihydropyridinyl)complexes and electron-rich arenes/olefins is reported. The reactionproceeds under mild reaction conditions so that a variety of functionalgroups are tolerated. Combined with a stereospecific annulative demetalation,the new reaction provides a rapid access to polycyclic alkaloid structures.The sequential protocol was used to prepare analogues of the antimalarialagent isofebrifugine. [ABSTRACT FROM AUTHOR]