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Simian Foamy Virus Infection of Rhesus Macaques in Bangladesh: Relationship of Latent Proviruses and Transcriptionally Active Viruses.

Authors :
Soliven, Khanh
Xiaoxing Wang
Small, Christopher T.
Feeroz, Mostafa M.
Eun-Gyung Lee
Craig, Karen L.
Hasan, Kamrul
Engel, Gregory A.
Jones-Engel, Lisa
Matsen IV, Frederick A.
Linial, Maxine L.
Source :
Journal of Virology. Dec2013, Vol. 87 Issue 24, p13628-13639. 12p.
Publication Year :
2013

Abstract

Simian foamy viruses (SFV) are complex retroviruses that are ubiquitous in nonhuman primates (NHP) and are zoonotically transmitted to humans, presumably through NHP saliva, by licking, biting, and other behaviors. We have studied SFV in freeranging rhesus macaques in Bangladesh. It has been previously shown that SFV in immunocompetent animals replicates to detectable levels only in superficial epithelial cells of the oral mucosa, although latent proviruses are found in most, if not all, tissues. In this study, we compare DNA sequences from latent SFV proviruses found in blood cells of 30 Bangladesh rhesus macaques to RNA sequences of transcriptionally active SFV from buccal swabs obtained from the same animals. Viral strains, defined by differences in SFV gag sequences, from buccal mucosal specimens overlapped with those from blood samples in 90% of animals. Thus, latent proviruses in peripheral blood mononuclear cells (PBMC) are, to a great extent, representative of viruses likely to be transmitted to other hosts. The level of SFV RNA in buccal swabs varied greatly between macaques, with increasing amounts of viral RNA in older animals. Evidence of APOBEC3-induced mutations was found in gag sequences derived from the blood and oral mucosa. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0022538X
Volume :
87
Issue :
24
Database :
Academic Search Index
Journal :
Journal of Virology
Publication Type :
Academic Journal
Accession number :
93454096
Full Text :
https://doi.org/10.1128/JVI.01989-13