Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKβ) and characterization of CaMKKβ and CaMKKα distribution in the adult mouse brain

The Ca2+/calmodulin-dependent protein kinase kinases alpha and beta (CaMKKs α and β) are novel members of the CaM kinase family. The CaMKKβ was cloned from mouse brain. The deduced amino acid sequence shared 96.43% homology with the rat CaMKKβ. Both the α and β isoforms were widely distributed throughout the adult mouse brain. Additionally, all peripheral tissues examined displayed CaMKK α and β expression. [Copyright &y& Elsevier]