Efficient prediction of protein conformational pathways based on the hybrid elastic network model.

Highlights: [•] We developed hybrid elastic network (HENM) model based on rigid cluster model. [•] HENM has been applied to both normal mode analysis and pathway generation. [•] The simulation results of selected proteins and ribosome show the robustness and reliability of the model. [•] HENM is expected to improve the computational efficiency of elastic network model. [Copyright &y& Elsevier]