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Taking a risk: a therapeutic focus on ataxin-2 in amyotrophic lateral sclerosis?
- Source :
-
Trends in Molecular Medicine . Jan2014, Vol. 20 Issue 1, p25-35. 11p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Intermediate polyQ expansions in ataxin-2 are strongly associated with amyotrophic lateral sclerosis (ALS). [•] Ataxin-2 plays a central role in RNA biology. [•] Ataxin-2 is a toxic modifier of TDP-43 and FUS pathology in ALS. [•] Ataxin-2 is a promising therapeutic target in ALS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14714914
- Volume :
- 20
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Trends in Molecular Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 93415105
- Full Text :
- https://doi.org/10.1016/j.molmed.2013.09.001