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CD36 deficiency and absent myocardial iodine-123-(R,S)-15-(p-iodophenyl)-3-methylpentadecanoic acid uptake in a girl with cardiomyopathy.
- Source :
-
European Journal of Pediatrics . 2003, Vol. 162 Issue 4, p264-266. 3p. - Publication Year :
- 2003
-
Abstract
- <bold>Unlabelled: </bold>A 10-year-old girl presented left ventricular failure 1 month after the onset of hemolytic uremic syndrome (HUS) caused by an Escherichia coli O157 infection and was diagnosed as having dilated cardiomyopathy. Thallium myocardial scintigraphy showed normal perfusion, but no myocardial uptake of iodine-123-( R, S)-15-( p-iodophenyl)-3-methylpentadecanoic acid ((123)I-BMIPP) was observed. We analyzed the CD36 expression in platelets and monocytes by using a flowcytometer, and she turned out to have CD36 deficiency type I.<bold>Conclusion: </bold>Some patients may be predisposed to myocardial damage in the presence of CD36 deficiency. It is necessary to clarify the etiological significance of the relationship between cardiac impairment and CD36 deficiency in children. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEMOLYTIC-uremic syndrome
*CARDIOMYOPATHIES
*PEDIATRIC cardiology
*LEFT heart ventricle
*HEART ventricle diseases
*ANTIGENS
*COMPARATIVE studies
*ESCHERICHIA coli
*ESCHERICHIA coli diseases
*FATTY acids
*RESEARCH methodology
*MEDICAL cooperation
*RADIOISOTOPES
*RESEARCH
*THALLIUM isotopes
*EVALUATION research
*BENZENE derivatives
*DILATED cardiomyopathy
*IODINE radioisotopes
*DISEASE complications
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 03406199
- Volume :
- 162
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- European Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 9338894
- Full Text :
- https://doi.org/10.1007/s00431-002-1118-2