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Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: Role of glycine conjugates.
- Source :
-
Toxicology in Vitro . Mar2014, Vol. 28 Issue 2, p218-230. 13p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Bile acid toxicity: glycine conjugated>unconjugated>taurine conjugated. [•] (Cheno)deoxycholate more toxic in day-1 SCRH than in day-3 SCRH. [•] Lower glycine conjugate levels in day-3 SCRH may explain this toxicity difference. [•] Decreased conjugates formation in day-3 SCRH drives lower glycine conjugate levels. [•] Canalicular/sinusoidal efflux contributes to decreased intracellular exposure. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 08872333
- Volume :
- 28
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Toxicology in Vitro
- Publication Type :
- Academic Journal
- Accession number :
- 93334369
- Full Text :
- https://doi.org/10.1016/j.tiv.2013.10.020