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Anti HSV-1 Flavonoid Derivatives Tethered with Houttuynin from Houttuynia cordata.
- Source :
-
Planta Medica . Dec2013, Vol. 79 Issue 18, p1742-1748. 7p. - Publication Year :
- 2013
-
Abstract
- This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of the new compounds was obtained as a pair of inseparable diasteriomeric epimers due to the chiral carbon of hemiketal at C-3". This phenomenon is rooted in the ring-chain tautomerism of the hemiketal functional group in solution, which was proved by dynamic NMR experiments. The new compounds 1-4 displayed inhibitory activities against herpes simplex virus 1, with respective IC50 values of 38.46, 14.10, 62.00 and 70.76 μM, which was associated with the medicinal functions of H. cordata. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ACYCLOVIR
*BIOLOGICAL assay
*FLAVONOIDS
*HERPESVIRUSES
*HIGH performance liquid chromatography
*MASS spectrometry
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*PHARMACEUTICAL chemistry
*REGRESSION analysis
*RESEARCH funding
*TOXICITY testing
*PHYTOCHEMICALS
*PLANT extracts
*DATA analysis software
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 00320943
- Volume :
- 79
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Planta Medica
- Publication Type :
- Periodical
- Accession number :
- 93312965
- Full Text :
- https://doi.org/10.1055/s-0033-1351051