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Organocatalytic Enantioselective Synthesis of 2,3-Allenoates by Intermolecular Addition of Nitroalkanes to Activated Enynes.
- Source :
-
Journal of the American Chemical Society . 12/4/2013, Vol. 135 Issue 48, p18020-18023. 4p. - Publication Year :
- 2013
-
Abstract
- The first efficient intermolecular addition of nitroalkanes to activated enynes for asymmetric synthesis of 2,3-allenoates is described. It is a new addition to the limited available strategies for catalytic asymmetric synthesis of allenoates. Enabled by a new bifunctional catalyst, a range of trisubstituted allenoates can be obtained in excellent chemical and optical purity. These allenoate products with a pendant 2-nitroethyl α-substituent are useful chiral building blocks. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 135
- Issue :
- 48
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 93312282
- Full Text :
- https://doi.org/10.1021/ja409080v