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Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53.

Authors :
Lee, Yoon-Jin
Park, Ihl-Sung
Lee, Yong-Jin
Shim, Jung-Hyun
Cho, Moon-Kyun
Nam, Hae-Seon
Park, Ji Woong
Oh, Myung-Ho
Lee, Sang-Han
Source :
Food & Chemical Toxicology. Jan2014, Vol. 63, p153-160. 8p.
Publication Year :
2014

Abstract

Highlights: [•] Resveratrol and clofarabine enhances a strong cytotoxicity with increased p53 activity. [•] Combination treatment of resveratrol and clofarabine enhances p53 transactivation. [•] The combined effect of resveratrol and clofarabine on apoptosis is synergistic. [•] Resveratrol could be useful to increase the efficacy of existing chemotherapy in the treatment of MM. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02786915
Volume :
63
Database :
Academic Search Index
Journal :
Food & Chemical Toxicology
Publication Type :
Academic Journal
Accession number :
93270601
Full Text :
https://doi.org/10.1016/j.fct.2013.11.004