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Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Feb2003, Vol. 13 Issue 4, p669. 5p. - Publication Year :
- 2003
-
Abstract
- We synthesized bicyclic ether sialidase inhibitors such as tetrahydro-furan-2-yl, tetrahydro-pyran-2-yl, and oxepan-2-yl derivatives related to zanamivir. These compounds substituted by diol at the C-3′ and C-4′ positions resulted in the retention of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. Compound 11a in particular showed comparable efficacy in vivo relative to that of oseltamivir phosphate. [Copyright &y& Elsevier]
- Subjects :
- *INFLUENZA
*DRUGS
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 13
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 9306721
- Full Text :
- https://doi.org/10.1016/S0960-894X(02)01039-9