A Randomized Trial of Genotype-Guided Dosing of Warfarin.

Authors :: Piromohamed, Munir
Burnside, Girvan
Eriksson, Niclas
Jorgensen, Andrew L.
Cheng Hock Toh
Nicholson, Toby
Kesteven, Patrick
Christersson, Christina
Wahlström, Bengt
Stafberg, Christina
Zhang, J. Eunice
Leathart, Julian B.
Kohnke, Hugo
Maitland-van der Zee, Anke H.
Williamson, Paula R.
Daly, Ann K.
Avert, Peter
Kamali, Farhad
Wadelius, Mia
Source :: New England Journal of Medicine. 12/12/2013, Vol. 369 Issue 24, p2294-2303. 10p. 3 Charts, 2 Graphs.
Publication Year :: 2013
Abstract: The article offers information on a study that compared the effect of genotype-guided dosing with that of standard dosing on anticoagulation control in patients starting warfarin therapy. The study conducted a multicenter, controlled trial involving patients with atrial fibrillation or venous thromboembolism. It found an association between pharmacogenetic-based dosing and higher percentage of time in the therapeutic international normalized ratio.