Systemic administration and local microinjection into the central nervous system of the 5-HT7 receptor agonist LP-211 modify the sleep-wake cycle in the rat.

Highlights: [•] Systemic administration of LP-211 increases wakefulness and reduces REM sleep. [•] Microinjection of LP-211 into the DRN, LC, BFB or LDT suppresses REM sleep. [•] Similar changes were described after administration of other 5-HT receptor agonists. [ABSTRACT FROM AUTHOR]