Quantitative determination of arenobufagin in rat plasma by ultra fast liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study.

Authors :: Li, Guoliang
Han, Weili
Jiang, Wei
Zhang, Dongmei
Ye, Wencai
Chen, Xiaojia
Ma, Ande
Source :: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. Nov2013, Vol. 939, p86-91. 6p.
Publication Year :: 2013
Abstract: Highlights: [•] A UFLC–MS method was developed to determination of arenobufagin in rat plasma. [•] A post-column switching valve was applied to reduce the matrix effect. [•] The method successfully applied to pharmacokinetic study of arenobufagin in rat plasma. [Copyright &y& Elsevier]

Subjects :: *QUANTITATIVE research
*LABORATORY rats
*CARDIAC glycosides
*BLOOD plasma
*LIQUID chromatography-mass spectrometry
*PHARMACOKINETICS
*POST-column derivatization (Chromatography)

Language :: English
ISSN :: 15700232
Volume :: 939
Database :: Academic Search Index
Journal :: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences
Publication Type :: Academic Journal
Accession number :: 92874110
Full Text :: https://doi.org/10.1016/j.jchromb.2013.09.019

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