Effects of estrone on the early life stages and expression of vitellogenin and estrogen receptor genes of Japanese medaka (Oryzias latipes).

Highlights: [•] We evaluate effect of E1 on the early life stage of Japanese medaka. [•] EI affected hatchability, time to hatching and the growth, deteriorated development. [•] E1 changed ERα and Vtg-I gene mRNA levels of both sexes at low concentrations. [•] E1 has unrecoverable impacts on medaka, even if only early life stages were exposed. [Copyright &y& Elsevier]