Optimization of the synthesis and study of stable aqueous dispersions of silver nanoparticles used in medicine.

Using chemical reduction, silver nanoparticle hydrosols were obtained and studied in a wide range of ratios of the initial reagents-NaBH 4: AgNO 3 from 0.1 to 10 and AOT: AgNO 3 from 0 to 1—where AOT is dioctyl sulfosuccinate sodium salt. Silver hydrosols are studied using transmission electron microscopy, dynamic light scattering, UV spectroscopy, and ionometry. The optimal ratios of the initial reagents are determined, which make it possible to obtain samples with a narrow particle size distribution of 2 to 20 nm and average size of silver nanoparticles of 10 nm. The samples synthesized are stable over an extended period of time (up to six months) and contain an insignificant amount of ionic silver, which makes them useful for application in medicine. [ABSTRACT FROM AUTHOR]