APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease.

Authors :: Parsa, Afshin
Kao, W. H. Linda
Dawei Xie
Astor, Brad C.
Man Li
Chi-yuan Hsu
Feldman, Harold I.
Parekh, Rulan S.
Kusek, John W.
Greene, Tom H.
Fink, Jeffrey C.
Anderson, Amanda H.
Choi, Michael J.
Wright Jr., Jackson T.
Lash, James P.
Freedman, Barry I.
Ojo, Akinlolu
Winkler, Cheryl A.
Raj, Dominic S.
Kopp, Jeffrey B.
Source :: New England Journal of Medicine. 12/5/2013, Vol. 369 Issue 23, p2183-2196. 14p. 4 Charts, 2 Graphs.
Publication Year :: 2013
Abstract: The article discusses research which investigated impact of the gene encoding apolipoprotein L1 (APOL1) variants on chronic kidney disease progression. It describes design, oversight and procedures of the African American Study of Kidney Disease and Hypertension (AASK) and the Chronic Renal Insufficiency Cohort (CRIC) study. It also explores end-stage renal disease risk for African American patients, APOL1 risk based on proteinuria status and APOL1 risk based on randomized blood pressure.