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Structure, enzymatic transformation and anticancer activity of branched high molecular weight laminaran from brown alga Eisenia bicyclis.

Authors :
Menshova, Roza V.
Ermakova, Svetlana P.
Anastyuk, Stanislav D.
Isakov, Vladimir V.
Dubrovskaya, Yuliya V.
Kusaykin, Mikhail I.
Um, Byung-Hun
Zvyagintseva, Tatiana N.
Source :
Carbohydrate Polymers. Jan2014, Vol. 99, p101-109. 9p.
Publication Year :
2014

Abstract

Highlights: [•] Structure of HMW laminaran EbL from Eisenia bicyclis was established. [•] EbL was investigated by chemical methods, NMR spectroscopy and mass spectrometry. [•] Laminaran was depolymerised by endo- and exo-glucanases from marine sources. [•] EbL and its oligomers inhibited colony formation of melanoma and colon cancer cells. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*MOLECULAR structure
*ENZYMATIC analysis
*ANTINEOPLASTIC agents
*MOLECULAR weights
*BROWN algae
*EISENIA (Algae)
*GLUCANS
*NUCLEAR magnetic resonance spectroscopy

Details

Language :
English
ISSN :
01448617
Volume :
99
Database :
Academic Search Index
Journal :
Carbohydrate Polymers
Publication Type :
Academic Journal
Accession number :
92653584
Full Text :
https://doi.org/10.1016/j.carbpol.2013.08.037
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