Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice.

Highlights: [•] A novel extract of natural herbal, tripchlorolide has anti-dementia action. [•] Long-term T4 treatment prevents learning and memory loss in aged SAMP8 mice. [•] T4 ameliorates hippocampal LTP in aged SAMP8 mice. [•] T4 alleviates synaptic plasticity dysfunction of the hippocampus. [•] T4 intensified the signal pathway of CaMKII-CREB-BDNF in SAMP8 mice. [Copyright &y& Elsevier]