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Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates.

Authors :
Wille, Timo
Kaltenbach, Lisa
Thiermann, Horst
Worek, Franz
Source :
Chemico-Biological Interactions. Dec2013, Vol. 206 Issue 3, p569-572. 4p.
Publication Year :
2013

Abstract

Highlights: [•] We investigated the effect of oximes on (de-)carbamylation of human AChE. [•] 2-PAM & obidoxime aggravated inhibition of AChE by carbaryl and propoxur. [•] Obidoxime had no impact on decarbamylation kinetics. [•] 2-PAM & obidoxime cannot be recommended in propoxur and carbaryl poisoned humans. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
00092797
Volume :
206
Issue :
3
Database :
Academic Search Index
Journal :
Chemico-Biological Interactions
Publication Type :
Academic Journal
Accession number :
92642976
Full Text :
https://doi.org/10.1016/j.cbi.2013.08.004