Inhalation toxicity of soman vapor in non-anesthetized rats: A preliminary assessment of inhaled bronchodilator or steroid therapy.

Highlights: [•] We developed a rodent inhalation exposure model for chemical warfare nerve agents. [•] Determined the LCt50 of soman in untreated, non-anesthetized rats. [•] Observed acute respiratory toxicity and lung injury following soman exposure. [•] Evaluated the efficacy of inhaled Combivent or Symbicort. [•] Treatments resulted in improvements in minute volume and edema, but not lethality. [ABSTRACT FROM AUTHOR]