GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis.

Highlights: [•] Cell-bound galectin-1 sequesters Lck from tumor cell/T-cell contact. [•] CD45 is required for Lck sequestration and the subsequent apoptotic response. [•] The GM1 ganglioside composition determines relocalization of Lck. [•] Membrane level of GM1 also affects the Gal-1 induced apoptosis of activated T-cells. [ABSTRACT FROM AUTHOR]