Hydrogel matrices containing single and mixed natural cyclodextrins. Mechanisms of drug release.

Highlights: [•] Single and mixed cyclodextrin hydrogels with controlled geometry have been synthesized. [•] Swelling profiles show the similarity of all the networks for single and mixed gels. [•] The Korsmeyer–Peppas model permits to identify in vitro drug release mechanisms. [•] The mixed polymers at pH 1.2 show non-Fickian release behaviour. [•] The coupling of diffusion and macromolecular relaxation mechanisms has been studied. [Copyright &y& Elsevier]