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Development of a new in vitro skin sensitization assay (Epidermal Sensitization Assay; EpiSensA) using reconstructed human epidermis.
- Source :
-
Toxicology in Vitro . Dec2013, Vol. 27 Issue 8, p2213-2224. 12p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Gene expression profile was examined in RhE model. [•] Five cellular stress related genes were significantly upregulated by DNFB and OXA. [•] Predictive performance of ATF3 gene displayed 100% accuracy to animal testing. [•] Tested four pre-/pro-haptens were correctly predicted by ATF3 and DNAJB4 genes. [•] A RhE-based assay could detect skin sensitizing potential of chemicals. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 08872333
- Volume :
- 27
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Toxicology in Vitro
- Publication Type :
- Academic Journal
- Accession number :
- 92501583
- Full Text :
- https://doi.org/10.1016/j.tiv.2013.08.007