Sesamol and naringenin reverse the effect of rotenone-induced PD rat model.

Highlights: [•] Neuroprotective effect of the sesamol and naringenin on rotenone-induced model of PD. [•] Bioflavonoids improve body weight and motor impairment of rotenone-induced PD model. [•] Antioxidant property of flavonoids protects neurons and muscles against degeneration. [•] Sesamol and naringenin restore level of protective proteins parkin, DJ1, TH and CHIP. [•] Sesamol and naringenin reduced caspase activation, ubiquitin expression in PD model. [Copyright &y& Elsevier]