Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway.

Highlights: [•] An inhibitor of kynurenine-3-monoxygenase was administered to pregnant female rats. [•] Adult offspring at postnatal day 60 (P60) showed alterations in synaptic plasticity. [•] Expression of GluN2A, sonic hedgehog and other developmental proteins was changed. [•] Most earlier protein changes had disappeared with no changes in RNA or learning tasks. [•] Prenatal kynurenine pathway inhibition produces persistent synaptic and protein changes. [Copyright &y& Elsevier]