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Efficacy of topical tacrolimus for the treatment of persistent pruritus ani in patients with atopic dermatitis.
- Source :
-
Journal of Dermatological Treatment . Dec2013, Vol. 24 Issue 6, p454-457. 4p. - Publication Year :
- 2013
-
Abstract
- Background: Pruritus ani (PA) is defined as intense chronic itching affecting perianal skin. Objective: We aimed to determine the efficacy of topical tacrolimus treatment in atopic dermatitis (AD) patients who have PA. Methods: The study included 32 patients with AD who were suffering PA. Patients were randomized into two groups. In total, 16 patients used 0.03% tacrolimus ointment and 16 patients used vaseline as placebo. All groups applied topical treatments to their perianal area twice daily for 4 weeks. The treatments were then reversed for 4 weeks after a 2 weeks wash out period. Results: In total, 32 patients with AD who had refractory anal itching were enrolled in this study. None of the patients had obtained successful results with previous treatments. There was a statistically significant decrease in the recorded EASI, DLQI and itching scores for the tacrolimus group compared to the placebo group at weeks 4 and 6 of treatment ( p < 0.05). Conclusion: Topical tacrolimus treatment was well tolerated and effective in controlling persistent PA in AD patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09546634
- Volume :
- 24
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Dermatological Treatment
- Publication Type :
- Academic Journal
- Accession number :
- 91967449
- Full Text :
- https://doi.org/10.3109/09546634.2013.800181