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The Association Between Hypotonia and Brain Tumors in Children With Neurofibromatosis Type 1.

The Association Between Hypotonia and Brain Tumors in Children With Neurofibromatosis Type 1.

Authors :
Wessel, Lauren E.
Albers, Anne C.
Gutmann, David H.
Dunn, Courtney M.
Source :
Journal of Child Neurology. Dec2013, Vol. 28 Issue 12, p1664-1667. 4p.
Publication Year :
2013

Abstract

Children with the neurofibromatosis type 1 (NF1) inherited tumor predisposition syndrome are at risk for the development of brain tumors. In addition, children with neurofibromatosis type 1 often exhibit low tone (hypotonia). In this study, the authors explored the hypothesis that hypotonia could be a clinical indicator of glioma in children with neurofibromatosis type 1. A total of 56 children between 1 and 7 years of age with a confirmed diagnosis of neurofibromatosis type 1 were evaluated. Brain magnetic resonance imaging (MRI) was available for 19 of these children. Chi-square analysis demonstrated a statistically significant correlation between hypotonia and glioma in children with neurofibromatosis type 1 (90% sensitivity and 78% specificity). These results suggest that hypotonia might be a clinically useful indicator of brain tumor in this at-risk population. [ABSTRACT FROM PUBLISHER]

Details

Language :
English
ISSN :
08830738
Volume :
28
Issue :
12
Database :
Academic Search Index
Journal :
Journal of Child Neurology
Publication Type :
Academic Journal
Accession number :
91947834
Full Text :
https://doi.org/10.1177/0883073812460918