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The Association Between Hypotonia and Brain Tumors in Children With Neurofibromatosis Type 1.
The Association Between Hypotonia and Brain Tumors in Children With Neurofibromatosis Type 1.
- Source :
-
Journal of Child Neurology . Dec2013, Vol. 28 Issue 12, p1664-1667. 4p. - Publication Year :
- 2013
-
Abstract
- Children with the neurofibromatosis type 1 (NF1) inherited tumor predisposition syndrome are at risk for the development of brain tumors. In addition, children with neurofibromatosis type 1 often exhibit low tone (hypotonia). In this study, the authors explored the hypothesis that hypotonia could be a clinical indicator of glioma in children with neurofibromatosis type 1. A total of 56 children between 1 and 7 years of age with a confirmed diagnosis of neurofibromatosis type 1 were evaluated. Brain magnetic resonance imaging (MRI) was available for 19 of these children. Chi-square analysis demonstrated a statistically significant correlation between hypotonia and glioma in children with neurofibromatosis type 1 (90% sensitivity and 78% specificity). These results suggest that hypotonia might be a clinically useful indicator of brain tumor in this at-risk population. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 08830738
- Volume :
- 28
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Child Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 91947834
- Full Text :
- https://doi.org/10.1177/0883073812460918