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CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen.
- Source :
-
Biochemical & Biophysical Research Communications . Nov2013, Vol. 441 Issue 2, p339-343. 5p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Tamoxifen produces cytotoxicity via estrogen-receptor (ER) independent mechanisms. [•] Tamoxifen binds to CB1 and CB2 cannabinoid receptors and acts as an inverse agonist. [•] CB1 and CB2 receptors are novel molecular targets for Tamoxifen. [•] ER-independent effects for Tamoxifen may be mediated via CB1 and/or CB2 receptors. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 441
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 91921259
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.10.057