ChemInform Abstract: Asymmetric Syntheses of Enantiopure C(5)-Substituted Transpentacins via Diastereoselective Ireland-Claisen Rearrangements.

Asymmetric syntheses of amino-methyl-cyclopentanecarboxylic acids are achieved in 9 steps from commercially available starting materials via Ireland-Claisen rearrangement of β-amino allyl esters (I), followed by ring-closure metathesis, reduction and deprotection. [ABSTRACT FROM AUTHOR]