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SIRT5 desuccinylates and activates SOD1 to eliminate ROS.
- Source :
-
Biochemical & Biophysical Research Communications . Nov2013, Vol. 441 Issue 1, p191-195. 5p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] SOD1 is succinylated and the succinylation decreases its activity. [•] SIRT5 binds to, desuccinylates and activates SOD1. [•] Mutation of SOD1 succinylation site inhibits the growth of lung tumor cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 441
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 91816491
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.10.033