Bidirectional modulation of hippocampal gamma (20–80Hz) frequency activity in vitro via alpha(α)- and beta(β)-adrenergic receptors (AR).

Highlights: [•] Noradrenaline causes a reduction in gamma frequency oscillations in the hippocampus in vitro. [•] Noradrenaline causes a reduction in IPSPs and EPSPs during gamma frequency activity. [•] Activation of alpha-adrenergic 1 receptors reduces gamma frequency activity. [•] Activation of beta-adrenergic 1 receptors increases gamma frequency activity. [•] Noradrenaline can bidirectionally modulate network gamma oscillations via activation of different receptor subtypes. [ABSTRACT FROM AUTHOR]