Expression alterations of cytochromes P4501A1, 2E1, and 3A, and their receptors AhR and PXR caused by 1-octyl-3-methylimidazolium chloride in mouse mammary carcinoma cells.

Authors :: Li, Xiaoyu
Ma, Junguo
Jing, Changqin
Wang, Jianji
Source :: Chemosphere. Nov2013, Vol. 93 Issue 10, p2488-2492. 5p.
Publication Year :: 2013
Abstract: Highlights: [•] C8mim[Cl] up-regulates the expressions of CYP1A1, CYP2E1, or CYP3A in EMT6 cells. [•] CYPs may be involved in the metabolization of imidazolium-based ionic liquids. [•] C8mim[Cl]-mediated CYP3A induction may be PXR-dependent. [ABSTRACT FROM AUTHOR]

Subjects :: *CYTOCHROME P-450
*GENE expression
*ARYL hydrocarbon receptors
*PREGNANE X receptor
*IMIDAZOLES
*MAMMARY gland cancer
*CANCER cells
*LABORATORY mice

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