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Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Dec2013, Vol. 23 Issue 23, p6325-6330. 6p. - Publication Year :
- 2013
-
Abstract
- Abstract: Herein, we report the synthesis and structure–activity relationship studies of new analogs of boceprevir 1 and telaprevir 2. Introduction of azetidine and spiroazetidines as a P2 substituent that replaced the pyrrolidine moiety of 1 and 2 led to the discovery of a potent hepatitis C protease inhibitor 37c (EC50 =0.8μM). [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 23
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 91725759
- Full Text :
- https://doi.org/10.1016/j.bmcl.2013.09.068