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Interleukin-24 Induces Neuroblastoma SH-SY5Y Cell Differentiation, Growth Inhibition, and Apoptosis by Promoting ROS Production.
- Source :
-
Journal of Interferon & Cytokine Research . Nov2013, Vol. 33 Issue 11, p709-714. 6p. - Publication Year :
- 2013
-
Abstract
- Neuroblastoma is among the most aggressive tumors that occur in childhood and infancy. The clinical prognosis of children with advanced-stage neuroblastoma is still poor. Interleukin-24 (IL-24) is emerging as a new cytokine involved in tumor cellular proliferation, differentiation, and apoptosis and has been widely studied as a tumor inhibitor. However, little is known about this cytokine's role in neuroblastoma. In this study, we investigated the possible effects of IL-24 on inducing neuroblastoma cell differentiation, growth inhibition, and apoptosis in vitro. Our data show that IL-24 promotes neuroblastoma SH-SY5Y cell differentiation, growth inhibition, and apoptosis. Furthermore, we found that the differentiation- and apoptosis-inducing action of IL-24 depends on the accumulation of reactive oxygen species (ROS). These results suggest that IL-24 can induce neuroblastoma cell differentiation and apoptosis and may be a potential therapeutic agent for neuroblastoma. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10799907
- Volume :
- 33
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Interferon & Cytokine Research
- Publication Type :
- Academic Journal
- Accession number :
- 91699549
- Full Text :
- https://doi.org/10.1089/jir.2013.0004