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Dosimetry of N6-FormyllysineAdducts Following [13C2H2]-FormaldehydeExposures in Rats.
- Source :
-
Chemical Research in Toxicology . Oct2013, Vol. 26 Issue 10, p1421-1423. 3p. - Publication Year :
- 2013
-
Abstract
- With formaldehyde as the major sourceof endogenous N6-formyllysine proteinadducts, we quantified endogenousand exogenous N6-formyllysine in the nasalepithelium of rats exposed by inhalation to 0.7, 2, 5.8, and 9.1 ppm[13C2H2]-formaldehyde using liquidchromatography-coupled tandem mass spectrometry. Exogenous N6-formyllysine was detected in the nasal epithelium,with concentration-dependent formation in total as well as fractionated(cytoplasmic, membrane, nuclear) proteins, but was not detected inthe lung, liver, or bone marrow. Endogenous adducts dominated at allexposure conditions, with a 6 h 9.1 ppm formaldehyde exposure resultingin one-third of the total load of N6-formyllysinebeing derived from exogenous sources. The results parallel previousstudies of formaldehyde-induced DNA adducts. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0893228X
- Volume :
- 26
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Chemical Research in Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 91556105
- Full Text :
- https://doi.org/10.1021/tx400320u