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Sequential Waves of Functionally Related Proteins Are Expressed When B Cells Prepare for Antibody Secretion
- Source :
-
Immunity (10747613) . Feb2003, Vol. 18 Issue 2, p243. 11p. - Publication Year :
- 2003
-
Abstract
- Upon encounter with antigen, B lymphocytes differentiate into Ig-secreting plasma cells. This step involves a massive development of secretory organelles, most notably the endoplasmic reticulum. To analyze the relationship between organelle reshaping and Ig secretion, we performed a dynamic proteomics study of B lymphoma cells undergoing in vitro terminal differentiation. By clustering proteins according to temporal expression patterns, it appeared that B cells anticipate their secretory role in a multistep process. Metabolic capacity and secretory machinery expand first to accommodate the mass production of IgM that follows. [Copyright &y& Elsevier]
- Subjects :
- *B cells
*IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 10747613
- Volume :
- 18
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Immunity (10747613)
- Publication Type :
- Academic Journal
- Accession number :
- 9142199
- Full Text :
- https://doi.org/10.1016/S1074-7613(03)00024-4