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Diminution of the NMDA receptor NR2B subunit in cortical and subcortical areas of WAG/Rij rats.

Diminution of the NMDA receptor NR2B subunit in cortical and subcortical areas of WAG/Rij rats.

Authors :
Karimzadeh, Fariba
Soleimani, Mansoureh
Mehdizadeh, Mehdi
Jafarian, Maryam
Mohamadpour, Maliheh
Kazemi, Hadi
Joghataei, Mohammad‐Taghi
Gorji, Ali
Source :
Synapse. Dec2013, Vol. 67 Issue 12, p839-846. 8p.
Publication Year :
2013

Abstract

ABSTRACT Modulation of glutamatergic NMDA receptors affects the synchronization of spike discharges in in WAG/Rij rats, a valid genetic animal model of absence epilepsy. In this study, we describe the alteration of NR2B subunit of NMDA receptors expression in WAG/Rij rats in different somatosensory cortical layers and in hippocampal CA1 area. Experimental groups were divided into four groups of six rats of both WAG/Rij and Wistar strains with 2 and 6 months of age. The distribution of NR2B receptors was assessed by immunohistochemical staining in WAG/Rij and compared with age-matched Wistar rats. The expression of NR2B subunit was significantly decreased in different somatosensory cortical layers in 2- and 6-month-old WAG/Rij rats. In addition, the distribution of NR2B in hippocampal CA1 area was lower in 6-month-old WAG/Rij compared with age-matched Wistar rats. The reduction of NR2B receptors in different brain areas points to disturbance of glutamate receptors expression in cortical and subcortical areas in WAG/Rij rats. An altered subunit assembly of NMDA receptors may underlie cortical hyperexcitability in absence epilepsy. Synapse 67:839-846, 2013. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08874476
Volume :
67
Issue :
12
Database :
Academic Search Index
Journal :
Synapse
Publication Type :
Academic Journal
Accession number :
91102366
Full Text :
https://doi.org/10.1002/syn.21687