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Diminution of the NMDA receptor NR2B subunit in cortical and subcortical areas of WAG/Rij rats.
Diminution of the NMDA receptor NR2B subunit in cortical and subcortical areas of WAG/Rij rats.
- Source :
-
Synapse . Dec2013, Vol. 67 Issue 12, p839-846. 8p. - Publication Year :
- 2013
-
Abstract
- ABSTRACT Modulation of glutamatergic NMDA receptors affects the synchronization of spike discharges in in WAG/Rij rats, a valid genetic animal model of absence epilepsy. In this study, we describe the alteration of NR2B subunit of NMDA receptors expression in WAG/Rij rats in different somatosensory cortical layers and in hippocampal CA1 area. Experimental groups were divided into four groups of six rats of both WAG/Rij and Wistar strains with 2 and 6 months of age. The distribution of NR2B receptors was assessed by immunohistochemical staining in WAG/Rij and compared with age-matched Wistar rats. The expression of NR2B subunit was significantly decreased in different somatosensory cortical layers in 2- and 6-month-old WAG/Rij rats. In addition, the distribution of NR2B in hippocampal CA1 area was lower in 6-month-old WAG/Rij compared with age-matched Wistar rats. The reduction of NR2B receptors in different brain areas points to disturbance of glutamate receptors expression in cortical and subcortical areas in WAG/Rij rats. An altered subunit assembly of NMDA receptors may underlie cortical hyperexcitability in absence epilepsy. Synapse 67:839-846, 2013. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08874476
- Volume :
- 67
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Synapse
- Publication Type :
- Academic Journal
- Accession number :
- 91102366
- Full Text :
- https://doi.org/10.1002/syn.21687