Role of SR Ca[sup 2+]-ATPase in contractile dysfunction of myocytes in tachycardia-induced heart failure.

Authors :: Igarashi-Saito, Keiko
Tsutsui, Hiroyuki
Yamamoto, Shimako
Takahashi, Masaru
Kinugawa, Shintaro
Tagawa, Hirofumi
Usui, Makoto
Yamamoto, Mitsutaka
Egashira, Kensuke
Takeshita, Akira
Source :: American Journal of Physiology. Jul98 Part 2 of 2, Vol. 275 Issue 1, pH31. 10p. 3 Black and White Photographs, 4 Diagrams, 1 Chart, 19 Graphs.
Publication Year :: 1998
Abstract: Determines the functional consequence of a decreased expression of sarcoplasmic reticulum (SR) Ca[sup 2+]-ATPase in tachycardia-induced heart failure. Myocyte contractile function and gene expression of SR Ca[sup 2+]-ATPase; Effects of thapsigargin and cyclopiazonic acid on contractile function and intracellular free Ca[sup 2+] concentration transient in normal myocytes.

Subjects :: *ADENOSINE triphosphatase
*CALCIUM channels
*SARCOPLASMIC reticulum
*HEART failure
*MUSCLE cells

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