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Chronic Myelomonocytic Leukemia Monocytes Uniformly Display a Population of Monocytes With CD11c Underexpression.
- Source :
-
American Journal of Clinical Pathology . Nov2013, Vol. 140 Issue 5, p686-692. 7p. 1 Chart, 3 Graphs. - Publication Year :
- 2013
-
Abstract
- Objectives: To examine the utility of CD11c expression on monocytes in normal controls and patients with chronic myelomonocytic leukemia (CMML) (n = 23) with flow cytometric immunophenotyping. Methods: Twenty-three CMML samples and 10 control bone marrows submitted for lymphoma staging without evidence of disease were examined. Results: Monocytes in CMML samples ranged from 4% to 35%. Expression of at least one aberrant monocytic marker was found on the monocytes in 18 (82%) of 22 evaluable cases. The most common aberrancy was underexpression of CD11c (n = 15), while none of the bone marrow controls showed underexpression of CD11c. Conclusions: A distinct heterogeneous population of monocytic cells with underexpression of CD11c was identified in all these cases. CD11c underexpression was independent of other aberrancies, including HLA-DR underexpression (n = 14), aberrant CD56 expression (n = 11), and underexpression of CD33, CD38, and CD14 (n = 6, 5, and 5, respectively), supporting the utility of CD11c expression status on monocytes in establishing a CMML diagnosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00029173
- Volume :
- 140
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- American Journal of Clinical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 90728345
- Full Text :
- https://doi.org/10.1309/AJCPUY0ZMG3VTLFG