Review: NSAIDs increase GI and CV events; coxibs increase mortality.

The article focuses on a meta-analysis that explored the risk for vascular and upper gastrointestinal (GI) events with nonsteroidal anti-inflammatory drugs (NSAIDs), and states that the study concluded that selective cyclooxygenase-2 (COX-2) inhibitors increase adverse outcomes compared with placebo, while traditional NSAIDs increase risk for heart failure hospitalization. It also presents comments on the meta-analysis and suggests that NSAIDs should be used at the lowest effective dose.