Dual role of IL-12 in the therapeutic efficacy or failure during combined PEG-Interferon-α2A and ribavirin therapy in patients with chronic hepatitis C.

Authors :: Araújo, Ana Ruth
Peruhype-Magalhães, Vanessa
Coelho-dos-Reis, Jordana Grazziela Alves
Chaves, Laura Patrícia Viana
Lima, Tatiane Amábili de
Pimentel, João Paulo Diniz
de Paula, Lúcia
Almeida, Carlos Maurício de
Tarragô, Andréa Monteiro
Tateno, Adriana
Levi, José Eduardo
Teixeira-Carvalho, Andrea
Martins-Filho, Olindo de Assis
Lira, Edson da Fonseca
Torres, Kátia Luz
Talhari, Sinésio
Malheiro, Adriana
Source :: Immunology Letters. Jul2013, Vol. 154 Issue 1/2, p61-69. 9p.
Publication Year :: 2013
Abstract: Highlights: [•] A broad but unguided cytokine storm is observed in the non-responder HCV patients. [•] SVR was associated with early decrease in the viral load. [•] A time-dependent increase on IL-12 levels was critical to support the SVR. [Copyright &y& Elsevier]

Subjects :: *CHRONIC hepatitis C
*INTERLEUKIN-12
*DRUG efficacy
*RIBAVIRIN
*CYTOKINES
*VIRAL load
*THERAPEUTICS

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